Stress and Arteriosclerosis

Toll-like receptors, endocrine stress response, and arteriosclerosis.

Response, and Arteriosclerosis To the Editor: There is increasing evidence that Toll-like receptor (TLR)dependent signaling and cell activation is critically involved in the pathogenesis of arteriosclerosis. The article by M. Kazemi et al impressively demonstrates that Toll-like receptor agonists induce lipid accumulation and proteins involved in atherosclerotic plaque development such as adipo...

Arteriosclerosis: facts and fancy.

Arterial vascular diseases comprise the leading cause of death in the industrialized world. Every physician learns about the pathology of these diseases in medical school. All pathologists evaluate arterial disease in surgical pathology and/or autopsy specimens. All clinicians encounter patients with clinical manifestations of these diseases. With such a common and clinically-important group of...

Experimental Arteriosclerosis

Arteriosclerotic lesions have been produced in monkeys (Macaca nemestrina) by selective removal of the vascular endothelium with an intra-arterial balloon catheter. Immediately after de-endothelialization a platelet layer covers the denuded area. This thrombus is gradually removed and by 7 days the vessel appears to be largely reendothelialized. Beginning at day 4, smooth muscle cells undergo m...

Vitamin B6 and arteriosclerosis.

In 1949, Rinehart and Greenberg reported that marked arteriosclerosis occurs in vitamin-B6-deficient monkeys. The present study investigates the relationship between vitamin B6 and arteriosclerosis and summarizes the results. I found that thrombogenesis, disorder of collagen metabolism and production of free radicals may be the processes that cause arteriosclerosis in human and experimental ani...

Spontaneous Arteriosclerosis in Rabbits